Synthesis and biological activity of the 1alpha,25-dihydroxyvitamin D3 diastereomer with unnatural configuration at the rings C/D side-chain moiety

S Marczak; A Przezdziecka; J Wicha; A Steinmeyer; U Zügel

doi:10.1016/s0960-894x(00)00598-9

Synthesis and biological activity of the 1alpha,25-dihydroxyvitamin D3 diastereomer with unnatural configuration at the rings C/D side-chain moiety

Bioorg Med Chem Lett. 2001 Jan 8;11(1):63-6. doi: 10.1016/s0960-894x(00)00598-9.

Authors

S Marczak¹, A Przezdziecka, J Wicha, A Steinmeyer, U Zügel

Affiliation

¹ Institute of Organic Chemistry, Polish Academy of Sciences, Warsaw.

PMID: 11140735
DOI: 10.1016/s0960-894x(00)00598-9

Abstract

1Alpha,25-dihydroxyvitamin D3 diastereomer, differing from the parent compound in configuration at four asymmetric carbon atoms in the rings C/D and side chain (C13, C14, C17 and C20), was synthesized and shown to have a significant affinity for the vitamin D receptor.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Calcitriol / chemical synthesis*
Calcitriol / chemistry
Calcitriol / metabolism*
Molecular Conformation
Molecular Structure
Protein Binding
Receptors, Calcitriol / metabolism*
Stereoisomerism

Substances

Receptors, Calcitriol
Calcitriol