Abstract
Inhibitors of the MAP kinase p38 are potentially useful for the treatment for osteoporosis, arthritis, and other inflammatory diseases. A series of thienyl, furyl, and pyrrolyl ureas has been identified as potent p38 inhibitors, displaying in vitro activity in the nanomolar range.
MeSH terms
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Arthritis / drug therapy*
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Enzyme Inhibitors / therapeutic use*
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Furans / chemical synthesis
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Furans / chemistry
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Furans / pharmacology
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Furans / therapeutic use
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Humans
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Inhibitory Concentration 50
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Interleukin-6 / antagonists & inhibitors
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Interleukin-6 / metabolism
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Mitogen-Activated Protein Kinases / antagonists & inhibitors*
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Molecular Structure
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Osteoporosis / drug therapy*
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Pyrroles / chemical synthesis
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Pyrroles / chemistry
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Pyrroles / pharmacology
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Pyrroles / therapeutic use
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Thiophenes / chemical synthesis
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Thiophenes / chemistry
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Thiophenes / pharmacology
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Thiophenes / therapeutic use
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Tumor Cells, Cultured
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Urea / analogs & derivatives*
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p38 Mitogen-Activated Protein Kinases
Substances
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Enzyme Inhibitors
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Furans
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Interleukin-6
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Pyrroles
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Thiophenes
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Urea
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Mitogen-Activated Protein Kinases
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p38 Mitogen-Activated Protein Kinases