Hyponatremia secondary to reset osmostat in a child with a central nervous system midline defect and a chromosomal abnormality

P Gupta; G Mick; C T Fong; N Jospe; K McCormick

doi:10.1515/jpem.2000.13.9.1637

Hyponatremia secondary to reset osmostat in a child with a central nervous system midline defect and a chromosomal abnormality

J Pediatr Endocrinol Metab. 2000 Nov-Dec;13(9):1637-41. doi: 10.1515/jpem.2000.13.9.1637.

Authors

P Gupta¹, G Mick, C T Fong, N Jospe, K McCormick

Affiliation

¹ Department of Pediatrics, University of Illinois, College of Medicine, Peoria, USA.

PMID: 11154161
DOI: 10.1515/jpem.2000.13.9.1637

Abstract

A newborn with a CNS midline defect and persistent hyponatremia was diagnosed with a "reset" osmostat using a 3% hypertonic saline test. The diagnosis was established by measuring urinary arginine vasopressin (UAVP) and plasma osmolality (P(Osmoil)). In this infant a chromosome abnormality with the karyotype 46, X, -X, +der(X) t(X;13) (p22.1;q22) was associated with the midline defect and a reset osmostat.

Publication types

Case Reports

MeSH terms

Arginine Vasopressin / metabolism*
Arginine Vasopressin / urine
Blood / metabolism
Chromosome Aberrations / genetics
Chromosome Disorders
Chromosomes, Human, Pair 13 / genetics
Female
Humans
Hyponatremia / diagnosis
Hyponatremia / etiology*
Hyponatremia / genetics
Infant, Newborn
Karyotyping
Osmolar Concentration
Saline Solution, Hypertonic
X Chromosome / genetics

Substances

Saline Solution, Hypertonic
Arginine Vasopressin