Abstract
Interleukin-18 (IL-18) plays a central role in the immune response by acting on Th1 cell differentiation, cell-mediated cytotoxicity and inflammation. The role of IL-18 in cancers and inflammatory diseases is discussed in the light of our investigations on IL-18 synthesis in normal colonic mucosa, colonic cancer and Crohn's disease (CD).
MeSH terms
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Colonic Neoplasms / immunology*
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Colonic Neoplasms / pathology
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Crohn Disease / immunology*
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Crohn Disease / pathology
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Humans
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Inflammation* / immunology
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Inflammation* / physiopathology
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Interleukin-18 / biosynthesis*
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Interleukin-18 / chemistry
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Interleukin-18 / physiology*
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Intestinal Mucosa / immunology*
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Intestinal Mucosa / metabolism