Prolonged effects of intraventricular galanin on a 5-hydroxytryptamine(1A) receptor mediated function in the rat

Neurosci Lett. 2001 Feb 16;299(1-2):145-9. doi: 10.1016/s0304-3940(00)01788-2.

Abstract

Galanin (3 nmol/rat), 2 h after its intracerebroventricular (i.c.v.) administration to male rats, attenuated the passive avoidance (PA) retention deficit induced by the 5-hydroxytryptamine (HT)(1A) receptor agonist 8-hydroxy-2-(di-N-propylamino)tetraline (8-OH-DPAT) (0.2 mg/kg) The reduction in the postjunctional 5-HT(1A) receptor-mediated response after i.c.v. galanin was not associated with changes in the mRNA levels and agonist binding properties of cortical limbic 5-HT(1A) receptors, believed to be the target receptors mediating the PA deficit caused by 8-OH-DPAT. These results suggest that acute increases of galanin transmission in vivo even after 2 h can counteract limbic 5-HT(1A) receptor-mediated responses of relevance for affective disorders without significantly affecting gene expression and binding characteristics of cortical limbic 5-HT(1A) receptors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 8-Hydroxy-2-(di-n-propylamino)tetralin / pharmacology
  • Animals
  • Avoidance Learning / drug effects*
  • Avoidance Learning / physiology
  • Behavior, Animal / drug effects
  • Behavior, Animal / physiology
  • Brain / drug effects*
  • Brain / metabolism
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / metabolism
  • Dose-Response Relationship, Drug
  • Drug Interactions / physiology
  • Galanin / metabolism*
  • Galanin / pharmacology*
  • Gene Expression Regulation / drug effects
  • Gene Expression Regulation / physiology
  • Injections, Intraventricular
  • Limbic System / drug effects
  • Limbic System / metabolism
  • Male
  • Mood Disorders / drug therapy
  • Mood Disorders / metabolism
  • Mood Disorders / physiopathology
  • RNA, Messenger / metabolism
  • Radioligand Assay
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Serotonin / drug effects*
  • Receptors, Serotonin / genetics
  • Receptors, Serotonin, 5-HT1
  • Serotonin / metabolism
  • Serotonin Receptor Agonists / pharmacology

Substances

  • RNA, Messenger
  • Receptors, Serotonin
  • Receptors, Serotonin, 5-HT1
  • Serotonin Receptor Agonists
  • Serotonin
  • 8-Hydroxy-2-(di-n-propylamino)tetralin
  • Galanin