Abstract
The increase in the extracellular potassium concentration ([K(+)](o)) is a well-established model of epilepsy (the so-called high potassium model). Therefore, it is generally accepted that for the prevention of abnormal excitability and seizure generation, increases of [K(+)](o) must be avoided. In this paper, however, we show that on the contrary, a reduction of [K(+)](o) also elicits epileptic activity in brain slices of man.
MeSH terms
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Adolescent
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Adult
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Child
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Child, Preschool
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Epilepsy, Complex Partial / chemically induced
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Epilepsy, Complex Partial / metabolism
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Epilepsy, Complex Partial / physiopathology*
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Epilepsy, Generalized / chemically induced
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Epilepsy, Generalized / metabolism
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Epilepsy, Generalized / physiopathology*
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Extracellular Space / metabolism
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Female
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Humans
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In Vitro Techniques
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Infant
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Male
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Middle Aged
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Neocortex / metabolism
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Neocortex / physiopathology*
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Potassium / pharmacology*