Abstract
Single intravenous injection of antidepressant tetrindol (1 and 10 mg/kg), a reversible monoamine oxidase A inhibitor, dose-dependently decreased heart rate and mean arterial pressure (in a concentration of 10 mg/kg) in alert NMRI mice and Sprague-Dawley rats. Nitric oxide synthase blockade with L-NAME attenuated tetrindol-induced bradycardia in rats and completely abolished this effect in mice.
MeSH terms
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Animals
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Antidepressive Agents / pharmacology*
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Blood Pressure / drug effects
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Carbazoles / pharmacology*
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Enzyme Inhibitors / pharmacology
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Heart Rate / drug effects
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Hemodynamics / drug effects*
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Male
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Mice
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Monoamine Oxidase Inhibitors / pharmacology
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NG-Nitroarginine Methyl Ester / pharmacology
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Nitric Oxide / biosynthesis
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Nitric Oxide Synthase / antagonists & inhibitors*
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Rats
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Rats, Sprague-Dawley
Substances
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Antidepressive Agents
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Carbazoles
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Enzyme Inhibitors
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Monoamine Oxidase Inhibitors
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tetrindole
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Nitric Oxide
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Nitric Oxide Synthase
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NG-Nitroarginine Methyl Ester