Abstract
Genotypic characteristics of human immunodeficiency virus type 1 (HIV-1) in Mexico were investigated in a multicenter study that involved centers in five geographic regions of the country. Study samples (n = 65) collected from male patients in 1998-1999 were sequenced within the C2-V5 region of the gp120 env gene. Phylogenetic analysis revealed that subtype B predominates in Mexico. The level of interpatient nucleotide diversity (mean value of 8.9%) was congruent with multiple introductions of the virus and the "aging" epidemic in Mexico. One-third of samples (30.8% of cases) showed polymorphism within the crown of the V3 loop demonstrating non-GPGR motifs. Two new motifs in the V3 loop crown - HPGG and GPEG - were observed. The evolution of the AIDS epidemic in Mexico should be closely monitored since non-B HIV-1 subtypes might be introduced. The nucleotide sequences were deposited in the GenBank under accession numbers AF200855-AF200869, AF200871-AF200892, and AF200894-AF200921.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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HIV Envelope Protein gp120 / genetics
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HIV Infections / epidemiology*
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HIV Infections / virology
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HIV-1 / classification
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HIV-1 / genetics*
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Humans
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Male
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Mexico / epidemiology
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Molecular Epidemiology*
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Molecular Sequence Data
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Phylogeny
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Sequence Analysis, DNA
Substances
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HIV Envelope Protein gp120
Associated data
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GENBANK/AF200855
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GENBANK/AF200856
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GENBANK/AF200857
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GENBANK/AF200858
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GENBANK/AF200859
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GENBANK/AF200860
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GENBANK/AF200861
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GENBANK/AF200862
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GENBANK/AF200863
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GENBANK/AF200864
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GENBANK/AF200865
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GENBANK/AF200866
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GENBANK/AF200867
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GENBANK/AF200868
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GENBANK/AF200869
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GENBANK/AF200871
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GENBANK/AF200872
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GENBANK/AF200873
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GENBANK/AF200874
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GENBANK/AF200875
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GENBANK/AF200876
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GENBANK/AF200877
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GENBANK/AF200878
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GENBANK/AF200879
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GENBANK/AF200880
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GENBANK/AF200881
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GENBANK/AF200882
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GENBANK/AF200883
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GENBANK/AF200884
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GENBANK/AF200885
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GENBANK/AF200886
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GENBANK/AF200887
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GENBANK/AF200888
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GENBANK/AF200889
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GENBANK/AF200890
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GENBANK/AF200891
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GENBANK/AF200892
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GENBANK/AF200894
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GENBANK/AF200895
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GENBANK/AF200896
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GENBANK/AF200897
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GENBANK/AF200898
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GENBANK/AF200899
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GENBANK/AF200900
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GENBANK/AF200901
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GENBANK/AF200902
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GENBANK/AF200903
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GENBANK/AF200904
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GENBANK/AF200905
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GENBANK/AF200906
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GENBANK/AF200907
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GENBANK/AF200908
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GENBANK/AF200909
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GENBANK/AF200910
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GENBANK/AF200911
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GENBANK/AF200912
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GENBANK/AF200913
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GENBANK/AF200914
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GENBANK/AF200915
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GENBANK/AF200916
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GENBANK/AF200917
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GENBANK/AF200918
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GENBANK/AF200919
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GENBANK/AF200920
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GENBANK/AF200921