Interleukin 10 expression is correlated with thrombospondin expression and decreased vascular involvement in colon cancer

Int J Oncol. 2001 Mar;18(3):487-91. doi: 10.3892/ijo.18.3.487.

Abstract

Interleukin 10 (IL-10) is an immuno-suppressive cytokine produced by T-lymphocytes, and a regulatory molecule for angiogenesis in various cancers. We examined IL-10 gene expression in 53 colon cancer patients who underwent surgical resection. IL-10 gene expression was correlated with TSP1 and TSP2 gene expression (P=0.0049, P=0.0285). Colon cancer with IL-10 gene expression (19/53) showed significantly decreased venous involvement (P=0.0433). The mean vessel counts in the colon cancers with IL-10 gene expression were significantly lower than those without IL-10 gene expression (P<0.001). These results suggested that IL-10 stimulates angiostatic factor gene expression, and results in suppression of venous involvement.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / blood supply
  • Adenocarcinoma / genetics
  • Adenocarcinoma / metabolism*
  • Adenocarcinoma, Mucinous / blood supply
  • Adenocarcinoma, Mucinous / genetics
  • Adenocarcinoma, Mucinous / metabolism*
  • Amino Acid Transport Systems*
  • Angiogenesis Inhibitors
  • Angiopoietin-1
  • Antigens, CD34 / analysis
  • Carrier Proteins / metabolism
  • Colonic Neoplasms / blood supply
  • Colonic Neoplasms / genetics
  • Colonic Neoplasms / metabolism*
  • DNA Primers / chemistry
  • Endothelial Growth Factors / metabolism
  • Female
  • Gene Expression Regulation / immunology*
  • Humans
  • Interleukin-10 / genetics
  • Interleukin-10 / metabolism*
  • Lymphokines / metabolism
  • Male
  • Membrane Glycoproteins / metabolism
  • Membrane Proteins / metabolism
  • Middle Aged
  • Neovascularization, Pathologic*
  • Proteins / metabolism
  • RNA, Messenger / analysis
  • Reverse Transcriptase Polymerase Chain Reaction
  • Saccharomyces cerevisiae Proteins*
  • Symporters*
  • Thrombospondin 1 / metabolism*
  • Thrombospondins / metabolism
  • Transcription, Genetic
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors

Substances

  • Agp2 protein, S cerevisiae
  • Amino Acid Transport Systems
  • Angiogenesis Inhibitors
  • Angiopoietin-1
  • Antigens, CD34
  • Carrier Proteins
  • DNA Primers
  • Endothelial Growth Factors
  • Lymphokines
  • Membrane Glycoproteins
  • Membrane Proteins
  • Proteins
  • RNA, Messenger
  • Saccharomyces cerevisiae Proteins
  • Symporters
  • Thrombospondin 1
  • Thrombospondins
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors
  • thrombospondin 2
  • Interleukin-10