Genetic and environmental influences on alcohol metabolism in humans

Alcohol Clin Exp Res. 2001 Jan;25(1):136-44.

Abstract

This manuscript represents the proceedings of a symposium at the 2000 RSA Meeting in Denver, Colorado. The organizer/chair was Ting-Kai Li. The presentations were: (1) Introduction to the Symposium, by Ting-Kai Li; (2) ALDH2 polymorphism and alcohol metabolism, by Shih-Jiun Yin; (3) ALDH2 promoter polymorphism and alcohol metabolism, by David W. Crabb; (4) Use of BrAC clamping to estimate alcohol elimination rates: Application to studies of the influence of genetic and environmental determinants, by Sean O'Connor; and (5) Effect of food and food composition on alcohol elimination rates as determined by clamping, by Vijay A. Ramchandani.

Publication types

  • Congress
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alcohol Dehydrogenase / genetics*
  • Alcohol Dehydrogenase / metabolism
  • Alcohol Drinking / genetics*
  • Alcohol Drinking / metabolism
  • Alcoholism / genetics*
  • Alcoholism / metabolism
  • Aldehyde Dehydrogenase / genetics*
  • Aldehyde Dehydrogenase / metabolism
  • Aldehyde Dehydrogenase, Mitochondrial
  • Central Nervous System Depressants / metabolism*
  • Central Nervous System Depressants / pharmacology
  • Diet
  • Environment*
  • Ethanol / metabolism*
  • Ethanol / pharmacology
  • Food
  • Genotype
  • Hemodynamics / drug effects
  • Hemodynamics / genetics
  • Humans
  • Polymorphism, Genetic

Substances

  • Central Nervous System Depressants
  • Ethanol
  • Alcohol Dehydrogenase
  • ALDH2 protein, human
  • Aldehyde Dehydrogenase
  • Aldehyde Dehydrogenase, Mitochondrial