Does [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]- dichloroplatinum(II) act on the hormone-sensitive, murine breast cancer as a biological response modifier? Part II. Studies on the influence of [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine] dichloroplatinum(II) on the specific immune defense in MXT-M-3,2 breast cancer bearing mice

Arch Pharm (Weinheim). 2000 Dec;333(12):397-403. doi: 10.1002/1521-4184(200012)333:12<397::aid-ardp397>3.0.co;2-f.

Abstract

The anti-tumor activity of [meso-1,2-bis(2,6-dichloro-4- hydroxyphenyl)ethylenediamine]dichloroplatinum(II) on the MXT-M-3,2 breast cancer implanted into B6D2F1 mice was not significantly reduced by splenectomy or co-administration of cyclosporine A. Neither did the use of T-lymphocyte-deficient NMRI (nu/nu) mice as hosts substantially influence its anti-tumor effect. Obviously, [meso-1,2-bis(2,6-dichloro-4- hydroxyphenyl)ethylenediamine]dichloroplatinum(II) does not act by an enhancement of the specific immune defense.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology*
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / immunology*
  • Cyclosporine / pharmacology
  • Female
  • Humans
  • Immunity / drug effects
  • Immunologic Factors / pharmacology*
  • Immunosuppressive Agents / pharmacology
  • Mice
  • Mice, Inbred Strains
  • Organoplatinum Compounds / pharmacology*
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / immunology
  • Transplantation, Heterologous
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Immunologic Factors
  • Immunosuppressive Agents
  • Organoplatinum Compounds
  • (1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine)dichloroplatinum (II)
  • Cyclosporine