Abstract
A novel method was used to obtain demethoxy amino-substituted hypocrellin derivatives. The reaction condition was mild and amino substitution occurred at position 2 or 11 of hypocrellins with high yield. The photophysical and photochemical properties of the amino-substituted hypocrellins derivatives were investigated, and their significantly enhanced red absorptivities and strong active oxygen-generating functions qualified them as promising photodynamic therapeutic anti-cancer agents.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Cell Survival / drug effects
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Electron Spin Resonance Spectroscopy
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HeLa Cells
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Humans
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Nuclear Magnetic Resonance, Biomolecular
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Perylene / analogs & derivatives
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Perylene / chemical synthesis*
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Perylene / chemistry
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Perylene / pharmacology
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Phenol
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Photochemistry
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Photosensitizing Agents / chemical synthesis*
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Photosensitizing Agents / chemistry
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Photosensitizing Agents / pharmacology
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Quinones / chemical synthesis*
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Quinones / chemistry
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Quinones / pharmacology
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Reactive Oxygen Species
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Superoxides / chemistry
Substances
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Antineoplastic Agents
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Photosensitizing Agents
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Quinones
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Reactive Oxygen Species
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Superoxides
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Phenol
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Perylene
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hypocrellin A