Abstract
It has been found that in vivo pretreatment of rats with the sigma receptor antagonist DuP 734 (1 mg/kg) resulted in an increase in the heart tolerance to ischemic and reperfusion arrhythmias both in vivo and ex vivo. Administration of DuP 734 (1 mg/liter) directly in the perfusion solution of isolated rat heart 10 min before total ischemia also promoted a decrease in the incidence of reperfusion arrhythmias. The normoxic perfusion of isolated rat heart at a dose of 1 mg/liter had no effect on the action potential. It was concluded that antiarrhythmic effect of DuP 734 might depend on the decrease in the Ca2+ overload but not on K+ and Na+ channel blockade.
MeSH terms
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Action Potentials
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Animals
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Anti-Arrhythmia Agents / pharmacology*
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Arrhythmias, Cardiac / etiology
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Arrhythmias, Cardiac / physiopathology
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Arrhythmias, Cardiac / prevention & control*
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Arterial Occlusive Diseases / complications
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Coronary Disease / complications
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Electrocardiography
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In Vitro Techniques
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Microelectrodes
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Myocardial Infarction / etiology
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Myocardial Infarction / pathology
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Myocardial Reperfusion Injury / etiology
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Myocardial Reperfusion Injury / physiopathology
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Myocardial Reperfusion Injury / prevention & control*
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Myocardium / metabolism
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Myocardium / pathology
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Narcotic Antagonists / pharmacology*
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Piperidines / pharmacology*
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Rats
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Rats, Wistar
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Receptors, sigma / antagonists & inhibitors*
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Receptors, sigma / metabolism
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Sclerosis / prevention & control
Substances
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Anti-Arrhythmia Agents
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Narcotic Antagonists
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Piperidines
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Receptors, sigma
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DuP 734