Structure-activity relationships for the analgesic activity of gallic acid derivatives

R Krogh; R A Yunes; A D Andricopulo

doi:10.1016/s0014-827x(00)00094-x

Structure-activity relationships for the analgesic activity of gallic acid derivatives

Farmaco. 2000 Nov-Dec;55(11-12):730-5. doi: 10.1016/s0014-827x(00)00094-x.

Authors

R Krogh¹, R A Yunes, A D Andricopulo

Affiliation

¹ College of Pharmacy, University of Michigan, Ann Arbor 48109, USA.

PMID: 11204950
DOI: 10.1016/s0014-827x(00)00094-x

Abstract

Values of ID50 for a collection of structurally-related gallic acid derivatives have been employed to create a predictive quantitative structure-activity relationship (QSAR) which links structure to values of analgesic activity. The QSAR model developed has substantial predictive power for the design of novel gallic acid derivatives having improved analgesic potency.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Analgesics, Non-Narcotic / chemical synthesis
Analgesics, Non-Narcotic / pharmacology*
Animals
Gallic Acid / analogs & derivatives*
Gallic Acid / chemical synthesis
Gallic Acid / pharmacology*
Mice
Models, Statistical
Pain Measurement / drug effects
Quantitative Structure-Activity Relationship

Substances

Analgesics, Non-Narcotic
Gallic Acid