Abstract
1,6-Naphthyridine-2-carboxylic acid benzylamides are potent anti-HCMV compounds. Replacement of the amide moiety by other groups containing internal hydrogen bonds was undertaken to extend the SAR. Our results indicated that the urca derivatives showed very good activity.
MeSH terms
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology
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Cell Survival / drug effects
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Cytomegalovirus / drug effects*
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Drug Design
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Hydrogen Bonding
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Inhibitory Concentration 50
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Naphthalenes / chemistry
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Naphthyridines / chemical synthesis
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Naphthyridines / pharmacology*
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Structure-Activity Relationship
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Thioamides / chemical synthesis
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Thioamides / chemistry
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Thioamides / pharmacology*
Substances
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Antiviral Agents
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Naphthalenes
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Naphthyridines
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Thioamides
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naphthalene