3-p-Toluoyl-2-[4'-(3-diethylaminopropoxy)-phenyl]-benzofuran and 2-[4'-(3-diethylaminopropoxy)-phenyl]-benzofuran do not act as surfactants or micelles when inhibiting the aggregation of beta-amyloid peptide

D Allsop; G Gibson; I K Martin; S Moore; S Turnbull; L J Twyman

doi:10.1016/s0960-894x(00)00645-4

3-p-Toluoyl-2-[4'-(3-diethylaminopropoxy)-phenyl]-benzofuran and 2-[4'-(3-diethylaminopropoxy)-phenyl]-benzofuran do not act as surfactants or micelles when inhibiting the aggregation of beta-amyloid peptide

Bioorg Med Chem Lett. 2001 Jan 22;11(2):255-7. doi: 10.1016/s0960-894x(00)00645-4.

Authors

D Allsop¹, G Gibson, I K Martin, S Moore, S Turnbull, L J Twyman

Affiliation

¹ Department of Biological Sciences, University of Lancaster, UK.

PMID: 11206472
DOI: 10.1016/s0960-894x(00)00645-4

Abstract

The cmc and IC50 values of the beta-amyloid (Abeta) aggregation inhibitors, 3-p-toluoyl-2-[4'-(3-diethylaminopropoxy)-phenyl]-benzofuran 1, and 2-[4'-(3-diethylaminopropoxy)-phenyl]-benzofuran 2 have been determined. After comparison of the cmc data and biological data (IC50 values), we conclude that these active benzofurans do not act as surfactants or micelles at the concentration required to inhibit beta-amyloid-peptide aggregation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amyloid beta-Peptides / antagonists & inhibitors*
Amyloid beta-Peptides / ultrastructure*
Benzofurans / chemistry
Benzofurans / pharmacology*
Dimerization
Dose-Response Relationship, Drug
Electric Conductivity
Inhibitory Concentration 50
Micelles
Nuclear Magnetic Resonance, Biomolecular
Peptides, Cyclic
Structure-Activity Relationship
Surface-Active Agents / pharmacology

Substances

2-(4'-(3-diethylaminopropoxy)-phenyl)-benzofuran
3-p-toluoyl-2-(4'-(3-diethylaminopropoxy)-phenyl)-benzofuran
Amyloid beta-Peptides
Benzofurans
Micelles
Peptides, Cyclic
Surface-Active Agents
pseudomycin B