Abstract
Twenty-four substituted 4-hydroxy-3-nitrocoumarins have been prepared for nitration of the corresponding 4-hydroxycoumarins. All were found to possess antiallergic activity as measured by the homocytotropic antibody-antigen induced passive cutaneous anaphylaxis reaction in the rat.
MeSH terms
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Animals
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Antigen-Antibody Reactions
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Coumarins / chemical synthesis*
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Coumarins / therapeutic use
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Hypersensitivity / drug therapy*
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Immunity, Cellular
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Isoantibodies
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Nitro Compounds / chemical synthesis
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Nitro Compounds / therapeutic use
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Passive Cutaneous Anaphylaxis
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Rats
Substances
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Coumarins
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Isoantibodies
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Nitro Compounds