Abstract
We have developed an efficient method and an automated synthetic system for the preparation of highly concentrated 188Re-MAG3. Routine production of 188Re-MAG3 for use in intracoronary radiation therapy was performed by compressed air driven semi-automated shielded system. 188Re-MAG3 was prepared with a commercial kit and reducing agents, purified and concentrated by C18 Sep-Pak cartridges to desired radioactivity and volume. Using this automated system, reproducible radiolabeling yields of 80-85% were obtained.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Angioplasty, Balloon, Coronary
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Automation
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Coronary Disease / radiotherapy*
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Coronary Disease / therapy
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Humans
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Methods
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Oligopeptides / chemical synthesis*
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Oligopeptides / therapeutic use*
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Organometallic Compounds / chemical synthesis*
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Organometallic Compounds / therapeutic use*
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Radioisotopes / therapeutic use*
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Radiopharmaceuticals / chemical synthesis*
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Radiopharmaceuticals / therapeutic use*
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Rhenium / therapeutic use*
Substances
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Oligopeptides
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Organometallic Compounds
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Radioisotopes
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Radiopharmaceuticals
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rhenium-mercaptoacetyltriglycine
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Rhenium