Abstract
We report a 5.5-year-old boy who underwent autologous peripheral blood stem cell transplantation for high-risk acute lymphoblastic leukemia and who had two abdominal masses develop 6 months later. Macroscopically complete resection of the abdominal tumors was performed and revealed a well-differentiated leiomyosarcoma. Smooth muscle tumors, benign or malignant, are increasingly recognized in children with various immunodeficiencies; the association with acute lymphoblastic leukemia is rarely described.
MeSH terms
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Abdominal Neoplasms / etiology*
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Abdominal Neoplasms / surgery
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Anthracyclines / administration & dosage
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Anthracyclines / adverse effects*
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / adverse effects*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Asparaginase / administration & dosage
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Asparaginase / adverse effects*
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Child, Preschool
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Cortisone / administration & dosage
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Cortisone / adverse effects*
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Disease Susceptibility
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Female
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Hematopoietic Stem Cell Transplantation*
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Humans
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Immunocompromised Host
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Immunologic Deficiency Syndromes / chemically induced
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Immunologic Deficiency Syndromes / complications*
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Immunologic Deficiency Syndromes / etiology
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Leiomyosarcoma / etiology*
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Leiomyosarcoma / surgery
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Leukemia-Lymphoma, Adult T-Cell / drug therapy*
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Leukemia-Lymphoma, Adult T-Cell / therapy
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Mercaptopurine / administration & dosage
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Mercaptopurine / adverse effects
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Neoplasms, Second Primary / etiology*
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Neoplasms, Second Primary / surgery
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Remission Induction
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Transplantation Conditioning / adverse effects*
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Transplantation, Autologous
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Vincristine / administration & dosage
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Vincristine / adverse effects*
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Whole-Body Irradiation / adverse effects*
Substances
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Anthracyclines
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Vincristine
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Mercaptopurine
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Asparaginase
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Cortisone