Synthesis and antitumor evaluation of novel monoindolyl-4-trifluoromethylpyridines and bisindolyl-4-trifluoromethylpyridines

B Jiang; X N Xiong; C G Yang

doi:10.1016/s0960-894x(00)00704-6

Synthesis and antitumor evaluation of novel monoindolyl-4-trifluoromethylpyridines and bisindolyl-4-trifluoromethylpyridines

Bioorg Med Chem Lett. 2001 Feb 26;11(4):475-7. doi: 10.1016/s0960-894x(00)00704-6.

Authors

B Jiang¹, X N Xiong, C G Yang

Affiliation

¹ Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, People's Republic of China.

PMID: 11229751
DOI: 10.1016/s0960-894x(00)00704-6

Abstract

A series of novel monoindolyl-4-trifluoromethylpyridines and bisindolyl-4-trifluoromethylpyridines was designed and synthesized as potential antitumor agents. They were evaluated for preliminary cytotoxic activity against P388 and A-549 cells with IC50 values. 4-Trifluoromethyl-2,6-bis[3'-(N-tosyl-6'-methoxyl-indolyl)] pyridine was identified as the most potent in this series.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology
Humans
Indoles / chemical synthesis*
Indoles / pharmacology
Leukemia P388 / drug therapy
Lung Neoplasms / drug therapy
Mice
Pyridines / chemical synthesis*
Pyridines / pharmacology

Substances

Antineoplastic Agents
Indoles
Pyridines