Meiotic recombination: Making and breaking go hand in hand

Curr Biol. 2001 Jan 23;11(2):R45-8. doi: 10.1016/s0960-9822(01)00013-6.

Abstract

Accurate segregation of homologous chromosomes at the first meiotic division requires the tight coordination of DNA replication, homologous recombination and chromosome organization. Recent studies suggest that the initiation of meiotic recombination is mechanistically coupled to premeiotic DNA replication.

MeSH terms

  • DNA Replication
  • Meiosis*
  • Recombination, Genetic*
  • Saccharomyces cerevisiae / genetics