The gait cycle involves a closely linked interplay among the joints of the lower extremity, notably the complex joints of the foot and ankle. The goals of bracing and orthoses in the management of neuromuscular foot and ankle problems are to prevent further deformity, passively correct deformity, and modulate motor tone. Tone-reducing AFO, in effect, improves the position of the lower extremity and facilitates the pathologic gait. The type of deformity present and its natural history by virtue of the pathologic origin must be considered when embarking on a conservative nonoperative course. Associated issues and thought processes are elaborated in the article. The biomaterials of which the orthotic brace is constructed, the design considerations, and expected goals of an orthosis must be appropriate to accommodate the pathomechanical forces encountered in the face of the cutaneous insensitivity. It is evident from the multiple facets of rehabilitative care that a team of professionals, including the orthopedist, physical therapist, and orthotist, along with involved health care workers, must be in communication and agreement to manage the challenges of these patients successfully.