[Primary gastric lymphomas. Clinico-pathological study and evaluation of prognostic factors in 65 cases treated surgically]

Pathologica. 2000 Dec;92(6):503-15.
[Article in Italian]

Abstract

Based on the histological criteria proposed by the REAL and adopted by the WHO Classification, 30 cases of MALT type lymphoma, 18 cases of diffuse large B cell lymphoma (DLCL), and 17 cases of DLCLs, associated with a MALT type, were identified in a series of 65 surgically treated primary gastric lymphomas. The clinical records of the patients were analyzed retrospectively and the resected specimens were immunostained for bcl-2, p53 and Ki-67. Primary gastric DLBCLs, with or without a MALT type component, disclosed a higher stage of local extension, a more frequent nodal involvement and a significantly worse survival than pure MALT types. High p53 expression and high proliferation rate correlated with the presence of a large cell component and appeared useful for its identification in mixed forms. Low bcl-2 expression discriminated DLCL from DLCL/MALT. Tumor size, stage and Mib-1 index revealed a value in predicting prognosis.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, Bacterial / analysis
  • Antigens, CD / analysis
  • Antigens, Nuclear
  • Biomarkers, Tumor / analysis
  • Combined Modality Therapy
  • Female
  • Gastritis / complications
  • Gastritis / microbiology
  • Helicobacter Infections / complications
  • Helicobacter pylori / immunology
  • Humans
  • Italy / epidemiology
  • Keratins / analysis
  • Ki-67 Antigen / analysis
  • Life Tables
  • Lymphoma, B-Cell, Marginal Zone / chemistry
  • Lymphoma, B-Cell, Marginal Zone / mortality
  • Lymphoma, B-Cell, Marginal Zone / pathology*
  • Lymphoma, B-Cell, Marginal Zone / surgery
  • Lymphoma, B-Cell, Marginal Zone / therapy
  • Lymphoma, Large B-Cell, Diffuse / chemistry
  • Lymphoma, Large B-Cell, Diffuse / mortality
  • Lymphoma, Large B-Cell, Diffuse / pathology*
  • Lymphoma, Large B-Cell, Diffuse / surgery
  • Lymphoma, Large B-Cell, Diffuse / therapy
  • Male
  • Middle Aged
  • Neoplasm Invasiveness
  • Neoplasm Proteins / analysis
  • Neoplasm Staging
  • Nuclear Proteins / analysis
  • Phenotype
  • Proto-Oncogene Proteins c-bcl-2 / analysis
  • Retrospective Studies
  • Stomach Neoplasms / chemistry
  • Stomach Neoplasms / mortality
  • Stomach Neoplasms / pathology*
  • Stomach Neoplasms / surgery
  • Stomach Neoplasms / therapy
  • Survival Analysis
  • Tumor Suppressor Protein p53 / analysis

Substances

  • Antigens, Bacterial
  • Antigens, CD
  • Antigens, Nuclear
  • Biomarkers, Tumor
  • Ki-67 Antigen
  • Neoplasm Proteins
  • Nuclear Proteins
  • Proto-Oncogene Proteins c-bcl-2
  • Tumor Suppressor Protein p53
  • Keratins