Aim: To study the effects of estrone on the bone resorption and bone formation in vitro.
Methods: Long bones from 16-day-old female mouse fetuses were cultured in BGJb medium for 48 h. The bones were harvested, then bones length and length of their diaphyses were measured under stereo microscope. The histomorphormetric analyses on midlongitudinal sections of bones were performed. The numbers of osteoclasts and hypertrophic chondrocytes were observed under biological microscope.
Results: Compared with control, there were significant increase in bones length and length of their diaphyses after treated with 10(-7) mol/L estrone. Under this condition, decreased osteoclasts and increased hypertrophic chondrocytes were observed, too.
Conclusion: Estrone stimulates bone formation and inhibites bone resorption in vitro.