Microkeratome-based limbal harvester for limbal stem cell transplantation: preliminary studies

Am J Ophthalmol. 2001 Mar;131(3):377-8. doi: 10.1016/s0002-9394(00)00801-1.

Abstract

Purpose: To develop a mechanical device to perform limbal transplantation. This procedure is a valuable surgical technique for management of limbal stem cell deficiency. However, the freehand dissection to obtain donor tissue is laborious and time-consuming.

Methods: A manual microkeratome (LSK One; Moria/Microtech, Doylestown, Pennsylvania) using a redesigned head (200 microm thickness, 16-mm blade) was used to create partial thickness corneoscleral caps from human donor globes.

Results: Corneoscleral caps obtained from human donor globes included a ring of approximately 1 mm of perilimbal sclera in contiguity to the cornea. Scanning electron microscopy showed a smooth cut surface with some chatter at the margins.

Conclusion: This instrument ensures an effective and straightforward method to dissect the area where stem cells have been indirectly localized.

MeSH terms

  • Cell Transplantation*
  • Corneal Diseases / surgery
  • Epithelial Cells / transplantation
  • Epithelial Cells / ultrastructure
  • Humans
  • Limbus Corneae / cytology*
  • Microscopy, Electron, Scanning
  • Ophthalmologic Surgical Procedures / instrumentation*
  • Stem Cell Transplantation*
  • Stem Cells / ultrastructure
  • Tissue and Organ Harvesting / methods*