Complementary 'bottom-up' and 'top-down' approaches to basal ganglia function

Curr Opin Neurobiol. 2000 Dec;10(6):725-31. doi: 10.1016/s0959-4388(00)00156-2.

Abstract

Recently, two quite different approaches exemplifying 'bottom-up' and 'top-down' philosophies have shed new light on basal ganglia function. In vitro work using organotypic co-cultures has implicated the subthalamic nucleus (STN) and the external segment of the globus pallidus (GP(e)) as pacemakers for low-frequency bursting that is reminiscent of the activity produced in Parkinsonian tremor. A circuit essential for avian song learning has been identified as part of the basal ganglia with surprisingly well conserved cellular details; investigation of this system may help to address general issues of basal ganglia function.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Basal Ganglia / physiology*
  • Movement / physiology*
  • Songbirds
  • Vocalization, Animal / physiology*