Abstract
Phosphoinositides play an integral role in a diverse array of cellular signaling processes. Although considerable effort has been directed toward characterizing the kinases that produce inositol lipid second messengers, the study of phosphatases that oppose these kinases remains limited. Current research is focused on the identification of novel lipid phosphatases such as PTEN and myotubularin, their physiologic substrates, signaling pathways and links to human diseases. The use of bioinformatics in conjunction with genetic analyses in model organisms will be essential in elucidating the roles of these enzymes in regulating phosphoinositide-mediated cellular signaling.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Apoptosis / physiology
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Cell Cycle / physiology
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Computational Biology
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Humans
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Molecular Sequence Data
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PTEN Phosphohydrolase
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Phosphatidylinositols / metabolism*
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Phosphoric Monoester Hydrolases / genetics
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Phosphoric Monoester Hydrolases / metabolism*
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Phylogeny
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Protein Tyrosine Phosphatases / genetics
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Protein Tyrosine Phosphatases / metabolism*
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Protein Tyrosine Phosphatases, Non-Receptor
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Sequence Homology, Amino Acid
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Tumor Suppressor Proteins*
Substances
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Phosphatidylinositols
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Tumor Suppressor Proteins
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Phosphoric Monoester Hydrolases
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Protein Tyrosine Phosphatases
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Protein Tyrosine Phosphatases, Non-Receptor
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myotubularin
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PTEN Phosphohydrolase
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PTEN protein, human