Abstract
The activities of cefotaxime and minocycline against Aeromonas hydrophila were investigated. Cefotaxime (4 times the MIC) plus minocycline (0.75 times the MIC) elicited an inhibitory effect for 48 h in a time-kill study, and more infected mice treated with both drugs survived (91%) than survived after treatment with cefotaxime (9%) or minocycline (44%) alone, suggesting that cefotaxime and minocycline act synergistically against A. hydrophila.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aeromonas hydrophila / drug effects*
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Animals
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use*
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Cefotaxime / pharmacology
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Cefotaxime / therapeutic use*
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Cephalosporins / pharmacology
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Cephalosporins / therapeutic use*
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Drug Synergism
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Drug Therapy, Combination / pharmacology
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Drug Therapy, Combination / therapeutic use*
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Gram-Negative Bacterial Infections / drug therapy*
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Kinetics
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Mice
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Microbial Sensitivity Tests
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Minocycline / pharmacology
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Minocycline / therapeutic use*
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Survival Analysis
Substances
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Anti-Bacterial Agents
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Cephalosporins
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Minocycline
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Cefotaxime