Abstract
Peptide mimetics of carbohydrates represent an alternative approach to induce anti-carbohydrate responses. Depending on their formulation, peptide mimetics can mediate T-independent or T-dependent responses. Multivalent peptide mimeotopes can induce high IgM/IgG ratios, as non-conjugated carbohydrates do. Here we observe that immunization with multivalent peptide mimeotope conjugated to BSA enhances carbohydrate reactive antibodies in Balb/c mice and xid mice, with IgG1 greater than IgG2a, in xid mice. These results suggest that mimeotope-conjugate formulations might augment carbohydrate-specific immune responses in immuno-compromised hosts.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Antibody Formation
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Antigens / chemistry*
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B-Lymphocytes / immunology
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Carbohydrates / chemistry
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Carbohydrates / immunology*
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Cross Reactions
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Female
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Immunization
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Lewis Blood Group Antigens / chemistry
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Lewis Blood Group Antigens / genetics
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Male
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Mice
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Mice, Inbred BALB C
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Mice, Inbred CBA
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Mice, Nude
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Models, Biological
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Molecular Mimicry*
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Molecular Sequence Data
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Peptides / genetics
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Peptides / immunology
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T-Lymphocytes / immunology
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Vaccines / immunology*
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Vaccines, Conjugate / pharmacology
Substances
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Antigens
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Carbohydrates
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Lewis Blood Group Antigens
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Lewis Y antigen
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Peptides
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Vaccines
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Vaccines, Conjugate