Synthesis and properties of peptide nucleic acids containing a psoralen unit

A Okamoto; K Tanabe; I Saito

doi:10.1021/ol015549x

Synthesis and properties of peptide nucleic acids containing a psoralen unit

Org Lett. 2001 Mar 22;3(6):925-7. doi: 10.1021/ol015549x.

Authors

A Okamoto¹, K Tanabe, I Saito

Affiliation

¹ Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, CREST, Japan Science and Technology Corporation (JST), Kyoto 606-8501, Japan.

PMID: 11263917
DOI: 10.1021/ol015549x

Abstract

We prepared the psoralen PNA unit from 8-methoxypsoralen and synthesized various PNAs containing psoralen by a typical (t)()Boc method. PNAs containing psoralen (P-PNA) at strand end formed a stable duplex with complementary DNA. The hybridization of P-PNA with complementary DNA resulted in a considerable decrease of the psoralen fluorescence.

MeSH terms

Base Sequence
DNA, Complementary / chemistry
Furocoumarins*
Indicators and Reagents
Nucleic Acid Hybridization
Oligodeoxyribonucleotides / chemistry
Peptide Nucleic Acids / chemical synthesis*
Peptide Nucleic Acids / chemistry
Spectrometry, Fluorescence
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Substances

DNA, Complementary
Furocoumarins
Indicators and Reagents
Oligodeoxyribonucleotides
Peptide Nucleic Acids