Abstract
Expression of a viral interleukin-6 (vIL-6) has been detected in certain Kaposi sarcoma (KS)--associated herpesvirus positive (KSHV(+)) lesions. The release of vIL-6 systemically and its contribution to the pathogenesis of HIV-related malignancies was studied. Serum vIL-6 was detected in 13 (38.2%) of 34 HIV(+) patients with KS, in 6 (85.7%) of 7 HIV(+) patients with primary effusion lymphoma (PEL) and/or multicentric Castleman disease (MCD), and in 18 (60.0%) of 30 HIV(+), mostly homosexual, individuals without KS, MCD, or PEL. By contrast, serum vIL-6 was detected in only 3 (23.1%) of 13 patients with classic KS, 1 (2.5%) of 40 blood donors from the United States, and 4 (19.0%) of 21 blood donors from Italy. Circulating vIL-6 levels were associated with HIV(+) status (P <.0001). However, within the HIV(+) cohort, serum vIL-6 levels were not associated with the occurrence of KSHV-associated malignancies (P =.43). (Blood. 2001;97:2173-2176)
MeSH terms
-
Anti-HIV Agents / therapeutic use
-
Antibodies, Viral / blood
-
Blood Donors
-
CD4-CD8 Ratio
-
Castleman Disease / blood*
-
Castleman Disease / classification
-
Castleman Disease / epidemiology
-
Castleman Disease / pathology
-
Castleman Disease / virology
-
Comorbidity
-
Enzyme-Linked Immunosorbent Assay
-
HIV Infections / blood
-
HIV Infections / complications
-
HIV Infections / drug therapy
-
HIV Infections / epidemiology
-
HIV Seronegativity
-
Herpesviridae Infections / blood*
-
Herpesviridae Infections / complications
-
Herpesviridae Infections / epidemiology
-
Herpesviridae Infections / virology
-
Herpesvirus 8, Human / genetics
-
Herpesvirus 8, Human / immunology
-
Herpesvirus 8, Human / isolation & purification
-
Herpesvirus 8, Human / pathogenicity*
-
Herpesvirus 8, Human / physiology
-
Humans
-
Immunoglobulin G / blood
-
Interleukin-6 / blood*
-
Italy / epidemiology
-
Japan / epidemiology
-
Lymphoma, AIDS-Related / blood*
-
Lymphoma, AIDS-Related / epidemiology
-
Lymphoma, AIDS-Related / virology
-
Sarcoma, Kaposi / blood
-
Sarcoma, Kaposi / epidemiology
-
Sarcoma, Kaposi / virology
-
United States / epidemiology
-
Viral Proteins / blood*
-
Virus Replication
Substances
-
Anti-HIV Agents
-
Antibodies, Viral
-
Immunoglobulin G
-
Interleukin-6
-
Viral Proteins