Abstract
Potent and selective EP3 receptor ligands were found by making a library using solid-support chemistry. These compounds can be obtained by a Suzuki coupling reaction of a solid-supported benzyl bromide using various boronic acids. The yields obtained for this reaction were in the range of 24-95% of arylmethyl cinnamic acid 1 after cleavage from the Wang resin.
MeSH terms
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Cinnamates / chemical synthesis*
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Cinnamates / chemistry
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Cinnamates / metabolism*
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Cinnamates / pharmacology
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Combinatorial Chemistry Techniques*
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Humans
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Ligands
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Molecular Structure
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Receptors, Prostaglandin E / antagonists & inhibitors*
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Receptors, Prostaglandin E / chemistry
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Receptors, Prostaglandin E / metabolism*
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Receptors, Prostaglandin E, EP3 Subtype
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Structure-Activity Relationship
Substances
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Cinnamates
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Ligands
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PTGER3 protein, human
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Receptors, Prostaglandin E
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Receptors, Prostaglandin E, EP3 Subtype
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cinnamic acid