Laryngeal amyloidosis is a very rare disease. In the upper airways, the most common localization is the laryngeal organ, particularly the supraglotic region. Usually laryngeal amyloidosis is a localized primary form, although it has occasionally been reported in conjunction with system amyloidosis. We are reporting a new case of localized primary laryngeal amyloidosis in the right arytenoid mucosa in a 66 years old woman who underwent CO2 laser endoscopic surgery.