Abstract
Genetic characterisation of herpes simplex virus type 1 (HSV-1) DNA isolated from a donor cornea before and after corneal transplantation demonstrated the transmission of HSV-1 through transplantation. This study is the first to provide conclusive evidence for the transmission of HSV-1 by penetrating keratoplasty with subsequent reactivation of donor-derived HSV-1 in the transplanted cornea.
Publication types
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Case Reports
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antibodies, Viral / blood
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DNA Fingerprinting
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Glaucoma / congenital*
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Glaucoma / surgery
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Herpesvirus 1, Human* / genetics
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Herpesvirus 1, Human* / immunology
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Humans
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Keratitis, Herpetic / immunology
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Keratitis, Herpetic / transmission*
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Keratitis, Herpetic / virology
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Keratoplasty, Penetrating*
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Male
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Polymerase Chain Reaction
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Reoperation
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Tissue Donors
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Virus Activation