Abstract
A novel synthetic strategy is described which may be used to prepare analogues of the antimalarial, fungal metabolite apicidin. Compared to the natural product, one analogue shows potent and selective activity in vitro against the parasite Trypanosoma brucei and low mammalian cell toxicity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Parasitic Sensitivity Tests
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Peptides, Cyclic / chemical synthesis*
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Peptides, Cyclic / chemistry
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Peptides, Cyclic / pharmacology
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Trypanocidal Agents / chemical synthesis*
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Trypanocidal Agents / chemistry
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Trypanocidal Agents / pharmacology
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Trypanosoma brucei brucei / drug effects
Substances
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Peptides, Cyclic
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Trypanocidal Agents
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apicidin