On the formation of steroidal amidoesters of 4-[N,N-bis(2-chloroethyl)amino]benzoic acid and their cytotoxic activity

C Camoutsis; C Sambani; D T Trafalis; P Peristeris

doi:10.1016/s0223-5234(00)80033-1

On the formation of steroidal amidoesters of 4-[N,N-bis(2-chloroethyl)amino]benzoic acid and their cytotoxic activity

Eur J Med Chem. 1999 Jul-Aug;34(7-8):645-9. doi: 10.1016/s0223-5234(00)80033-1.

Authors

C Camoutsis¹, C Sambani, D T Trafalis, P Peristeris

Affiliation

¹ Laboratory of Pharmaceutical Chemistry, Department of Pharmacy, University of Patras, 26100, Patras, Greece.

PMID: 11278049
DOI: 10.1016/s0223-5234(00)80033-1

Abstract

The 4-[N,N-bis(2-chloroethyl)amino]benzoate of 17beta-acetamido-5alpha-androstan-3beta-ol, 17beta-acetamido-5-androsten-3beta-ol, 3beta-acetamido-5alpha-androstan-17beta-ol and 3alpha-acetamido-5beta-androstan-17beta-ol have been prepared and their antineoplastic effect evaluated against MIA Pa-Ca-2 pancreatic carcinoma, T47D breast carcinoma and A431 squamus cell carcinoma. Among the compounds tested, the compound 17beta-acetamido-3beta-hydroxy-5-androsten-4-[N, N-bis(2-chloroethyl)amino]benzoate appeared to possess a significant cytotoxic effect against A431 cells.

MeSH terms

Adenocarcinoma / drug therapy
Adenocarcinoma / pathology
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology*
Carcinoma / drug therapy
Carcinoma / pathology
Cell Division / drug effects
Esters / chemical synthesis*
Esters / pharmacology*
Humans
Prednisolone / chemical synthesis*
Prednisolone / pharmacology*
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Esters
Prednisolone