Abstract
Spectroscopic methods covering many energy regions together provide complementary insight into metalloenzyme active sites. These methods probe geometric and electronic structure and define these contributions to reactivity. Two recent advances--determination of the polarizations of electronic transitions in solution using magnetic circular dichroism, electron paramagnetic resonance and quantum chemistry, and experimental estimation of covalency using metal L-edges and ligand K-edges--are particularly important.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Binding Sites / physiology
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Bleomycin / analysis
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Bleomycin / chemistry
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Chemistry, Bioinorganic*
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Circular Dichroism
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Electromagnetic Fields
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Electron Spin Resonance Spectroscopy / methods
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Ligands
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Metalloproteins / analysis*
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Metalloproteins / chemistry
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Metals / chemistry
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Quantum Theory
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Spectrum Analysis / methods
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Spectrum Analysis / trends*
Substances
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Ligands
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Metalloproteins
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Metals
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Bleomycin