Abstract
Parasite genome projects are generating an avalanche of sequence data. If this resource is to be exploited effectively for drug and vaccine design, there is an urgent need to make the link between these DNA sequences and the functional proteins of the parasite, which they encode. Here, we seek to demystify the revolutionary advances in protein identification based on mass spectrometry.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Brugia malayi / genetics
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Genome*
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Genome, Protozoan
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Helminth Proteins* / chemistry
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Leishmania / genetics
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Mass Spectrometry / methods
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Molecular Sequence Data
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Phosphopyruvate Hydratase / chemistry
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Plasmodium / genetics
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Proteome*
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Protozoan Proteins* / chemistry
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Schistosoma mansoni / genetics
Substances
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Helminth Proteins
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Proteome
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Protozoan Proteins
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Phosphopyruvate Hydratase