Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions

Nat Med. 2001 Apr;7(4):383-5. doi: 10.1038/86397.
No abstract available

Publication types

  • Letter

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Apoptosis Regulatory Proteins
  • Drug Evaluation, Preclinical
  • Hepatocytes / cytology
  • Hepatocytes / drug effects*
  • Humans
  • In Vitro Techniques
  • Ligands
  • Macaca fascicularis
  • Membrane Glycoproteins / chemistry
  • Membrane Glycoproteins / therapeutic use
  • Membrane Glycoproteins / toxicity*
  • Mice
  • Neoplasms / drug therapy
  • Recombinant Proteins / chemistry
  • Recombinant Proteins / therapeutic use
  • Recombinant Proteins / toxicity
  • Safety
  • TNF-Related Apoptosis-Inducing Ligand
  • Tumor Cells, Cultured
  • Tumor Necrosis Factor-alpha / chemistry
  • Tumor Necrosis Factor-alpha / therapeutic use
  • Tumor Necrosis Factor-alpha / toxicity*

Substances

  • Apoptosis Regulatory Proteins
  • Ligands
  • Membrane Glycoproteins
  • Recombinant Proteins
  • TNF-Related Apoptosis-Inducing Ligand
  • TNFSF10 protein, human
  • Tnfsf10 protein, mouse
  • Tumor Necrosis Factor-alpha