Non-convulsive status epilepticus in two patients receiving tiagabine add-on treatment

J Neurol. 2001 Feb;248(2):109-12. doi: 10.1007/s004150170244.

Abstract

We report two patients with epileptic syndromes who developed non-convulsive status epilepticus under adjunctive antiepileptic therapy with tiagabine. The paradoxical effect may be the result of a difference in effects between GABAA and GABAB receptors, or between GABA receptors in different regions of the brain.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anticonvulsants / adverse effects*
  • Anticonvulsants / pharmacology
  • Anticonvulsants / therapeutic use*
  • Brain / physiopathology
  • Drug Therapy, Combination
  • Electroencephalography
  • Epilepsy, Complex Partial / drug therapy*
  • Female
  • Humans
  • Middle Aged
  • Nipecotic Acids / adverse effects*
  • Nipecotic Acids / pharmacology
  • Nipecotic Acids / therapeutic use*
  • Receptors, GABA / physiology
  • Status Epilepticus / chemically induced*
  • Status Epilepticus / physiopathology*
  • Tiagabine

Substances

  • Anticonvulsants
  • Nipecotic Acids
  • Receptors, GABA
  • Tiagabine