Divergent and convergent evolution of NK-cell receptors

Trends Immunol. 2001 Jan;22(1):52-7. doi: 10.1016/s1471-4906(00)01802-0.

Abstract

Natural killer (NK)-cell receptors specific for major histocompatibility complex (MHC) class I molecules have been identified in humans and mice. Some of the most important receptors are structurally unrelated in the two species: the murine Ly-49 receptors are C-type lectins, while human killer-cell inhibitory receptors (KIRs) belong to the immunoglobulin superfamily. Here, Roland Barten and colleagues describe the divergent and convergent evolution of NK-cell receptors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Evolution, Molecular*
  • Humans
  • Killer Cells, Natural / chemistry
  • Killer Cells, Natural / immunology
  • Killer Cells, Natural / metabolism*
  • Receptors, Immunologic / chemistry*
  • Receptors, Immunologic / genetics
  • Receptors, Immunologic / physiology*
  • Receptors, KIR
  • T-Lymphocyte Subsets / chemistry*
  • T-Lymphocyte Subsets / immunology

Substances

  • Receptors, Immunologic
  • Receptors, KIR