Abstract
Treatment of ovariectomized female rats with estrogen for 2 days reduces alpha2-adrenoceptor binding density by 25%, increases G protein coupled receptor kinase (GRK) activity by 50% and elevates GRK 2 protein levels by 50% in the frontal cortex. These results suggest that estrogen may decrease alpha2-adrenoceptor expression in the frontal cortex of female rats by regulating GRK 2.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cyclic AMP-Dependent Protein Kinases / metabolism*
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Estradiol / pharmacology*
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Female
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Frontal Lobe / drug effects*
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Frontal Lobe / metabolism*
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G-Protein-Coupled Receptor Kinase 2
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Rats
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Rats, Sprague-Dawley
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Sex Characteristics*
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beta-Adrenergic Receptor Kinases
Substances
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Estradiol
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Cyclic AMP-Dependent Protein Kinases
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Grk2 protein, rat
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beta-Adrenergic Receptor Kinases
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G-Protein-Coupled Receptor Kinase 2