Pneumolysin potentiates production of prostaglandin E(2) and leukotriene B(4) by human neutrophils

R Cockeran; H C Steel; T J Mitchell; C Feldman; R Anderson

doi:10.1128/IAI.69.5.3494-3496.2001

Pneumolysin potentiates production of prostaglandin E(2) and leukotriene B(4) by human neutrophils

Infect Immun. 2001 May;69(5):3494-6. doi: 10.1128/IAI.69.5.3494-3496.2001.

Authors

R Cockeran¹, H C Steel, T J Mitchell, C Feldman, R Anderson

Affiliation

¹ Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, Institute for Pathology, University of Pretoria, Pretoria, South Africa. [email protected]

Abstract

Exposure to pneumolysin (8.37 and 41.75 ng/ml) caused a calcium-dependent increase in the generation of prostaglandin E(2) and leukotriene B(4) by both resting and chemoattractant-activated human neutrophils in vitro. These interactions of pneumolysin with neutrophils may result in dysregulation of inflammatory responses during pneumococcal infection.

MeSH terms

Adult
Bacterial Proteins
Dinoprostone / biosynthesis*
Humans
Leukotriene B4 / biosynthesis*
N-Formylmethionine Leucyl-Phenylalanine / pharmacology
Neutrophils / drug effects*
Neutrophils / metabolism
Pneumococcal Infections / immunology
Streptolysins / pharmacology*

Substances

Bacterial Proteins
Streptolysins
plY protein, Streptococcus pneumoniae
Leukotriene B4
N-Formylmethionine Leucyl-Phenylalanine
Dinoprostone