Decreased cytotoxicity and increased antimitotic activity of proline analogue of chlorambucil as a prodrug in breast cancer MCF-7 cells

MeSH terms

• Antineoplastic Agents, Alkylating / pharmacology*
• Breast Neoplasms / drug therapy
• Breast Neoplasms / pathology
• Chlorambucil / pharmacology*
• DNA / biosynthesis
• Dipeptidases / metabolism*
• Dose-Response Relationship, Drug
• Female
• Humans
• Mitosis / drug effects*
• Prodrugs / metabolism
• Prodrugs / pharmacology*
• Proline / pharmacology*
• Tumor Cells, Cultured