Klebsiella pneumoniae meningitis in thalassemia major patients

Pediatr Hematol Oncol. 2001 Apr-May;18(3):229-32. doi: 10.1080/08880010151114949.

Abstract

Two thalassemia major patients received regular blood transfusion and desferrioxamine chelation, and 1 patient had a splenectomy at 9 years of age. Both patients developed Klebsiella pneumoniae meningitis at age of 27 and 15 years. They died within a short time despite appropriate antibiotic treatment. Klebsiella meningitis may be more common in transfusion-dependent thalassemia patients.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Blood Transfusion
  • Cefotaxime / therapeutic use
  • Ceftazidime / therapeutic use
  • Cefuroxime / therapeutic use
  • Cephalosporins / therapeutic use*
  • Deferoxamine / therapeutic use
  • Fatal Outcome
  • Humans
  • Klebsiella Infections / complications
  • Klebsiella Infections / diagnosis
  • Klebsiella Infections / drug therapy*
  • Klebsiella pneumoniae / isolation & purification*
  • Male
  • Meningitis, Bacterial / complications
  • Meningitis, Bacterial / diagnosis
  • Meningitis, Bacterial / drug therapy*
  • Splenectomy
  • beta-Thalassemia / complications*
  • beta-Thalassemia / therapy

Substances

  • Cephalosporins
  • Ceftazidime
  • Deferoxamine
  • Cefotaxime
  • Cefuroxime