Aims: Twenty lactic acid bacteria strains were isolated from human faeces and tested by MTT assay for stimulation or inhibition of the proliferation of Vero and myeloma cells.
Methods and results: None of the strains significantly affected the proliferation of Vero cells. However, two isolates (HN1 and HA8) showed a strong inhibition of myeloma cell proliferation (16.7 and 5.0%, respectively) by MTT assay.
Conclusion: Both strains have an anti-proliferative effect on a tumoral cell line.
Significance and impact of the study: The beneficial effect of LAB cancer therapy has been linked to their ability for immunomodulation.