The short-term effects of terazosin in Japanese men with benign prostatic hyperplasia

J Nippon Med Sch. 2001 Apr;68(2):181-5. doi: 10.1272/jnms.68.181.

Abstract

We evaluated the short-term efficacy of terazosin for treating symptomatic benign prostatic hyperplasia (BPH). Thirty men, aged 52 to 83 years (mean: 69.2 years) complaining of obstructive urinary symptoms due to BPH who had not received any prior treatment for their symptoms were orally administered 2 mg/day of terazosin. Symptoms (the total IPSS and the obstructive and irritative symptom scores) and objective parameters (peak flow rate [Qmax] and prostatic volume) were evaluated before treatment and after 1, 2, and 4 weeks of treatment. The mean total IPSS and the mean symptom scores for weak stream and nocturia were significantly decreased after only 1 week of treatment, while the mean scores for emptying, frequency, and urgency were significantly decreased after 2 weeks of treatment. However, the mean scores for intermittency and hesitancy did not decrease significantly at any time during treatment. Regarding objective parameters, the mean Qmax was significantly improved after 1 week of treatment, but the mean prostatic volume remained almost unchanged after 4 weeks. In conclusion, short-term terazosin therapy not only improved Qmax but also alleviated symptoms including irritative symptoms.

MeSH terms

  • Adrenergic alpha-Antagonists / therapeutic use*
  • Aged
  • Aged, 80 and over
  • Drug Administration Schedule
  • Humans
  • Male
  • Middle Aged
  • Prazosin / analogs & derivatives*
  • Prazosin / therapeutic use*
  • Prostatic Hyperplasia / drug therapy*
  • Prostatic Hyperplasia / physiopathology
  • Urination
  • Urodynamics

Substances

  • Adrenergic alpha-Antagonists
  • Terazosin
  • Prazosin