Abstract
From the leaf surface exudate of the aerial parts of Salvia cinnabarina a new secoisopimarane diterpenoid with a non-specific spasmolytic activity on histamine-, acetylcholine-, and barium chloride-induced contractions in the isolated guinea-pig ileum was obtained. The IC50 value obtained was comparable with that obtained for papaverine. The structure of 3,4-secoisopimara-4(18),7,15-triene-3-oic acid was established by 1D and 2D NMR spectroscopic techniques.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Acetylcholine / metabolism
-
Animals
-
Diterpenes / isolation & purification*
-
Diterpenes / pharmacology
-
Guinea Pigs
-
Histamine / metabolism
-
Ileum / drug effects
-
In Vitro Techniques
-
Lamiaceae
-
Magnetic Resonance Spectroscopy
-
Male
-
Molecular Structure
-
Papaverine / pharmacology
-
Parasympatholytics / isolation & purification*
-
Parasympatholytics / pharmacology
-
Plant Leaves / chemistry
-
Plants, Medicinal / chemistry*
Substances
-
3,4-secoisopimara-4(18),7,15-triene-3-oic acid
-
Diterpenes
-
Parasympatholytics
-
Histamine
-
Papaverine
-
Acetylcholine