Abstract
Multifunctional protein 14 (MFP-14) is a ubiquitous protein that inhibits the production of tumor necrosis factor alpha (TNF-alpha) and gamma interferon (IFN-gamma), which are involved in the pathogenesis of sepsis. Here, lipopolysaccharide (LPS)-induced lethality in mice was markedly reduced by MFP-14. The treatment also lowered LPS-induced levels of TNF-alpha and IFN-gamma in the blood.
MeSH terms
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Adjuvants, Immunologic / therapeutic use*
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Animals
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Disease Models, Animal
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Endotoxemia / chemically induced
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Endotoxemia / drug therapy
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Endotoxemia / metabolism
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Endotoxemia / prevention & control*
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Female
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Heat-Shock Proteins / therapeutic use*
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Interferon-gamma / metabolism
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Lipopolysaccharides
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Mice
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Mice, Inbred BALB C
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Proteins*
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Ribonucleases*
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Treatment Outcome
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Tumor Necrosis Factor-alpha / metabolism
Substances
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Adjuvants, Immunologic
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Heat-Shock Proteins
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Lipopolysaccharides
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MFP14 protein, mouse
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Proteins
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Tumor Necrosis Factor-alpha
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Interferon-gamma
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Ribonucleases