Treatment of acute leukemia in protected environment units

Cancer. 1979 Aug;44(2):431-6. doi: 10.1002/1097-0142(197908)44:2<431::aid-cncr2820440209>3.0.co;2-4.

Abstract

Thirty evaluable patients with acute leukemia (AL), aged 14 to 48-year-old received remission induction chemotherapy on a protected environment-prophylactic antibiotic program. Twenty-seven (90%) of these patients achieved complete remission and 17 remained in complete remission for 1 to 22 months. Although these patients spent 36% of their time with neutrophil counts less than 100/mm3, they spent only 20% of their time with fever. Major infection was present during only 7% of the days when neutrophil count was less than 100/mm3. No patient died of an infectious complication during remission induction therapy.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Anti-Bacterial Agents / administration & dosage
  • Antineoplastic Agents / administration & dosage
  • Drug Therapy, Combination
  • Environment, Controlled*
  • Female
  • Humans
  • Infection Control
  • Leukemia, Lymphoid / therapy*
  • Leukemia, Myeloid, Acute / therapy*
  • Male
  • Middle Aged
  • Patient Isolation*
  • Remission, Spontaneous

Substances

  • Anti-Bacterial Agents
  • Antineoplastic Agents